Mortality in Children with Severe Hand, Foot and Mouth Disease in Guangxi, China
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Date
2018-02
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Indian Academy of Pediatrics
Abstract
Objective: To analyze the clinical features of children with hand foot and mouth disease(HFMD) who died. Methods: 331 deaths due to HFMD between 2010 and 2014 wereincluded in this retrospective study; 15 autopsies were performed. Results: Most deathswere seen in children aged below 3 y, and with enterovirus 71 infection (91%). The mean(SD) duration of HFMD from onset to death was 3.7(2.9) d. The mean (SD) age of fastprogressors (from onset to death less than 4 days) was 17.4 (9.2) mo. Most of them werediagnosed as stage 3 and stage 4 of HFMD. Various pathological changes were observed inbrain after autopsy, especially in brain stem and medulla. Conclusions: The brain stemencephalitis with the neurotropism of enteroviruses seems to be the main contributor to thedeath in HFMD
Description
Keywords
Complications, Enterovirus, Epidemiology, Mortality
Citation
Zhi-Yong Yang , Xiu-Qi Chen , Dan Sun , Dan Wei. Mortality in Children with Severe Hand, Foot and Mouth Disease in Guangxi, China. Indian Pediatrics. 2018 Feb; 55(2): 137-139