Post-Ranibizumab injection endophthalmitis in aggressive posterior retinopathy of prematurity
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Date
2019-06
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
All India Ophthalmological Society
Abstract
A preterm infant with zone 1 aggressive posterior retinopathy of prematurity developed infectious endophthalmitis after intravitreal injection of ranibizumab. Urgent empirical intravitreal therapy with vancomycin, ceftazidime, and dexamethasone along with intravenous therapy with amikacin and meropenem helped in early resolution. Vascularization/activity of disease subsided on follow-up, media cleared, and laser photocoagulation was completed. Later the disease reactivated, developed vitreous membranes and central retinal traction, for which 25-gauge lens-sparing vitrectomy was performed. Emergent treatment helped in salvaging the eye from both aggressive ROP disease and devastating endophthalmitis. Rationale approach to such a case is being discussed.
Description
Keywords
Endophthalmitis, ranibizumab, retinopathy of prematurity, vascular endothelial growth factor
Citation
Chandra P, Kumawat D, Tewari R, Azimeera S. Post-Ranibizumab injection endophthalmitis in aggressive posterior retinopathy of prematurity. Indian Journal of Ophthalmology. 2019 Jun; 67(6): 967-969