Extensive trophoblastic differentiation in case of an endometrial carcinoma

Trophoblastic differentiation of endometrial carcinoma is extremely rare, till date 18 cases reports are there in the literature. A 68-year-old postmenopausal female presented with abnormal vaginal bleeding. Histopathologically, there were areas of serous carcinoma with trophoblastic differentiation (~90%). On immunohistochemistry, the trophoblastic component was positive for ?-human chorionic gonadotropin (hCG), HPL and EMA. IHC confirmed the diagnosis of serous carcinoma with trophoblastic differentiation. The clinicopathological features of 18 previously reported cases of trophoblastic differentiation in the uterine tumor were analyzed in addition to the present case.

Keywords

Endometrium, serous carcinoma, trophoblast

Citation

Yadav S, Sagar N, Mallya V, Mandal S, Khurana N, Gupta S. Extensive trophoblastic differentiation in case of an endometrial carcinoma. Indian Journal of Pathology and Microbiology. 2018 Dec; 61(4): 614-616

URI

https://imsear.searo.who.int/handle/123456789/196270

Collections

Indian Journal of Pathology & Microbiology

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