Hepatitis B & C virus infection in HIV seropositive individuals & their association with risk factors: A hospital-based study

Thumbnail Image
Files
ijmr2018v147n6p588.pdf (423.41 KB)
Date
2018-06
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Indian Council of Medical Research
Abstract
Background & objectives: Hepatitis B and hepatitis C virus (HBV and HCV) cause acute and chronic hepatitis, and infections with HBV and HCV are common in HIV-infected patients. The present study was conducted to determine the co-infection of hepatitis B and C virus in stored serum samples of HIV-positive/negative individuals attending an Integrated Counselling and Testing Centre (ICTC) in north India and their association with certain risk factors. Methods: This study included a total of 840 serum samples, of which 440 were from HIV seropositive individuals and 400 were from control individuals seeking voluntary check-up of HIV status at ICTC. Serum samples were used for the detection of HBV and HCV infection. Results: HBV infection (11%) was found to be less in contrast to HCV (13%) amongst the HIV seropositive. In controls, HBV and HCV infection was two and three per cent, respectively. Co-infection of HBV and HCV was found in 15 of 109, and in controls, it was 2 of 15. Age group between 21 and 40 was significantly associated with HBV and HCV infection. Heterosexual contact was the leading mode of acquiring HBV and HCV infection. Interpretation & conclusions: HBV and HCV co-infection was found to be significantly higher in HIV-positive individuals in comparison to normal population. Hepatitis virus infection leads to rapid progression of liver cirrhosis in HIV-infected patients. Routine check-up of HIV seropositive patients for hepatitis virus may be required to monitor clinical outcome.
Description
Keywords
Co-infection, hepatitis B, hepatitis C, HIV
Citation
Sharma V, Ramachandran V G, Mogha NS, Bharadwaj M. Hepatitis B & C virus infection in HIV seropositive individuals & their association with risk factors: A hospital-based study. Indian Journal of Medical Research. 2018 Jun; 147(6): 588-593
URI
https://imsear.searo.who.int/handle/123456789/195557
Collections
Indian Journal of Medical Research