A curious case of Lepromatous Leprosy Developing Complete loss of Pigmentation, followed by Reappearance of Pigmentation with Multi Drug Therapy (MDT) alone - A Support for Neural Theory of Vitiligo Pathogenesis?
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Date
2018-06
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Publisher
Hind Kusht Nivaran Sangh (Indian Leprosy Association)
Abstract
Lepromatous leprosy is a multisystem disease characterized by a decline in delayed hypersensitivity to Mycobacterium leprae antigens, causing multiplication of bacilli in huge numbers. We herein report a case of an adult male with lepromatous leprosy who was started on adult multibacillary multi-drug therapy. With treatment, the surface of lesions developed depigmented macules and patches. However, on continuation of antileprotic drugs, there was progressive perifollicular as well as inter-follicular re-pigmentation. This case clinically depicts re-pigmentation of depigmented skin following multidrug therapy for leprosy supporting the role of neural system in the homeostasis of melanocytes.
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Keywords
Lepromatous leprosy, Depigmentation, Multidrug therapy, Vitiligo, Neural theory
Citation
Kumar P, Savant SS, Das A. A curious case of Lepromatous Leprosy Developing Complete loss of Pigmentation, followed by Reappearance of Pigmentation with Multi Drug Therapy (MDT) alone - A Support for Neural Theory of Vitiligo Pathogenesis?. Indian Journal of Leprosy. 2018 Jun; 90(2): 155-159