Evaluation of aspartate amino transferase to platelet ratio index as a non invasive marker for liver cirrhosis
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Date
2019-03
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Medip Academy
Abstract
Background: Cirrhosis is a condition in which the liver slowly deteriorates and is unable to function normally due to chronic long lasting injury. Liver biopsy is considered as a gold standard for the diagnosis of cirrhosis and has many problems like bleeding, infective peritonitis which limit use of liver biopsies in all patients.Methods: A comparative study was done (90 cases and 90 controls) who fulfilled the inclusion criteria in a tertiary center.Results: The present study was conducted using a total of 180 participants, 90 USG diagnosed cases of liver cirrhosis was compared with 90 healthy controls. The mean AST level in the cirrhosis was 66.50±27.06 as compared to 21.26±6.52 in controls which was statistically significant. In this study the sensitivity and specificity of APRI was found to be 100.0% and 84.44% respectively, and the positive and negative predictive values were 86.54% and 100% respectively with significantly Area under the curve (AUC) (0.999, P>0.01).Conclusions: A simple index like Aspartate platelet ratio index, consisting of 2 readily available laboratory results (AST level and platelet count), can predict cirrhosis with a high degree of accuracy.
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Keywords
Aspartate platelet ratio index, Aspartate amino transferase, Complete blood count, Cirrhosis, Liver function test, Ultrasound
Citation
Feros Mohammed, Shanmugam Lokesh. Evaluation of aspartate amino transferase to platelet ratio index as a non invasive marker for liver cirrhosis. International Journal of Advances in Medicine. 2019 Mar; 6(2): 216-221