Cognitive impairment and 30-day rehospitalization rate in patients with acute heart failure: A systematic review and meta-analysis

Background Heart failure (HF) is one of the world leading causes of hospitalization and rehospitalization. Cognitive impairment has been identified as a risk factor for rehospitalization in patients with heart failure. However, previous studies reported mixed results. Therefore, we conducted a systematic review and meta-analysis to assess the association between cognitive impairment and 30-day rehospitalization in patients with HF. Method We performed a comprehensive literature search through July 2018 in the databases of MEDLINE and EMBASE. Included studies were cohort studies, case-control studies, cross-sectional studies or randomized controlled trials that compared the risk of 30-day rehospitalization in HF patients with cognitive impairment and those without. We calculated pooled relative risk (RR) with 95% confidence intervals (CI) and I2 statistic using the random-effects model. Results Five studies with a total of 2,342 participants (1,004 participants had cognitive impairment) were included for meta-analysis. In random-effect model, cognitive impairment significantly increased the risk of 30-day rehospitalization in HF participants (pooled RR=1.63, 95%CI: 1.19-2.24], I2=64.2%, p=0.002). Subgroup analysis was performed on the studies that excluded patients with dementia. The results also showed that cognitive impairment significantly increased the risk of 30-day rehospitalization in participants with HF (pooled RR=1.29, 95%CI: 1.05–1.59, I2=0.0%, p=0.016), which was consistent with our overall analysis. Conclusion Our meta-analysis demonstrated that the presence of cognitive impairment is associated with 30-day rehospitalization in patients with HF.

Keywords

heart failure, cognitive impairment, cognitive dysfunction, rehospitalization

Citation

Kewcharoen Jakrin, Trongtorsak Angkawipa, Kanitsoraphan Chanavuth, Prasitlumkum Narut, Mekritthikrai Raktham, Techorueangwiwat Chol, Limpruttidham Nath, Rattanawong Pattara. Cognitive impairment and 30-day rehospitalization rate in patients with acute heart failure: A systematic review and meta-analysis. Indian Heart Journal. 2019 Jan; 71(1): 52-59

URI

https://imsear.searo.who.int/handle/123456789/191728

Collections

Indian Heart Journal

Full item page