Inhibition of Mmp-9 Expression through Nf-Kβ by Natural Compounds as a Possible Therapeutic Adjuvant Strategy in Breast Cancer: A Systematic Review
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Date
2019-10
Journal Title
Journal ISSN
Volume Title
Publisher
Science Domain International
Abstract
MMP-9 expression may be induced at the transcriptional level in response to different agents. Due to its fundamental role in cancer progression, the control of MMP expression, especially MMP-9, is the possible target of future adjuvant therapies that seek to reduce metastases and angiogenesis in women with breast cancer. Therefore, the aim of this study was to search in the literature available evidences of extracts/or natural compounds that have potential therapeutic capacity to inhibit MMP-9 expression. Extracts and/or natural compounds identified in this review play a significant role in the inhibition of MMP-9 expression via NF-kβ, and may act on the prevention of metastases from primary breast tumors. The majority of the studies found have shown that natural products are capable of suppressing migration and invasion of breast cancer cells, thus inhibiting the formation of in vitro metastases. Further studies are warranted to understand the potential mechanisms of breast cancer metastasis from signaling cascades intrinsic to the tumor. Moreover, the NF-kβ, followed by Mitogen Activated Protein Kinases / Activator protein 1 (MAPK / AP-1) were the major pathways affected by the extracts and / or compounds studied. These pathways are directly linked to MMP-9 expression.
Description
Keywords
Inhibitor, matrix metalloproteinase, metastasis, breast cancer
Citation
Oliveira Victor Alves de, Chagas Diego Cipriano, Amorim Jefferson Rodrigues, Nogueira Thaís Rodrigues, Nogueira Thais Alves, Pereira Renato de Oliveira, Martins Luana Mota, Rodrigues Gilmara Peres, Sousa João Marcelo de Castro e, da Silva Felipe Cavalcanti Carneiro, da Silva Benedito Borges. Inhibition of Mmp-9 Expression through Nf-Kβ by Natural Compounds as a Possible Therapeutic Adjuvant Strategy in Breast Cancer: A Systematic Review. European Journal of Medicinal Plants. 2019 Oct; 29(2): 1-9