Comparative Study of Metformin and Combination of Metformin and Sitagliptin in Type II Diabetic Mellitus Patients
Loading...
Date
2019-07
Journal Title
Journal ISSN
Volume Title
Publisher
Society for Health Care & Research Development
Abstract
Metformin is recommended as initial monotherapy for treatment of type 2 diabetes mellitus because it decreases the higher blood glucose by suppressing hepatic production of glucose, apart from suppression of hepatic glucose production, it also increases sensitivity of insulin, it also enhances the peripheral uptake of glucose (by inducing GLUT4 enhancer factor phosphorylation), and it also decreases the insulin-induced suppression of fatty acid oxidation. The aim of this study, metformin and combination of metformin and sitagliptin in type ii diabetic mellitus patients. Methods: Two groups were included in this study. Each group has 50 cases & each case was having diabetic mellitus. This study conducted in the Career Institute of Medical Sciences in the Department of Pharmacology. The duration of study was over a period of six month. Results: In our study we were included two groups. Each group has 50 cases, means total 100 cases were included. In group I we were observed 26 male & 24 female out of 50 cases. In group I we found that 13 had vomiting followed by diarrhea, metallic taste, abdominal pain. While in group II we found that 3 had vomiting followed by diarrhea, metallic taste, abdominal pain. Conclusion: The foregone discussion revealed that in patients who are on monotherapy with metformin alone having inadequate glycaemic control. The addition of one daily dose of Sitagliptin 100 mg is the most effective way of maintaining glycaemic control.
Description
Keywords
Diabetes Mellitus, Metformin, Sitagliptin
Citation
Singh Abhijeet, Meherunisa, Jaiswal Sapna, Anand Bhupinder, Singh Marwaha Manvinder Pal. Comparative Study of Metformin and Combination of Metformin and Sitagliptin in Type II Diabetic Mellitus Patients. Annals of International medical and Dental Research. 2019 Jul; 5(4): 16-19