Therapeutic Targets on Toxoplasma gondii Parasite in Combatting Toxoplasmosis
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Date
2019-06
Journal Title
Journal ISSN
Volume Title
Publisher
Science Domain International
Abstract
The status of toxoplasmosis management is challenged by drug intolerance, compromised efficacy and potential development of drug resistance. However, currently, there are very limited targets on T. gondii that serve as the site of action of current medications. This review aimed to explore more potential targets that are essential to parasite survival and are absent in humans. Many unexplored targets on T. gondii exist and their specificities to the parasite make them ideal drug targets. The present review had searched relevant English databases such as PubMed, Scopus, Google scholar and Science Direct, for relevant literature on the therapeutic target of T. gondii. Many of the enzyme systems in several pathways are essentially palatable as drug targets. Establishing compounds that can target these enzymes on T. gondii will greatly be beneficial in treating acute and chronic toxoplasmosis in humans.
Description
Keywords
Toxoplasmosis, T gondii, essential, drug, targets, enzymes
Citation
Abdullahi Sharif Alhassan, Unyah Ngah Zasmy, Nordin Noshariza, Basir Rusliza, Wana Mohammed Nasir, Alapid Ashraf Ahmad, Hassan Yahaya, Tijjani Mustapha, Majid Roslaini Abd. Therapeutic Targets on Toxoplasma gondii Parasite in Combatting Toxoplasmosis. Annual Research & Review in Biology. 2019 Jun; 32(2): 1-15