Blandm-1 Gene Carriage In The Icu Of Tertiary Care Hospital In North India
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Date
2019-02
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World Wide Journals
Abstract
BACKGROUND:- New Delhi metallo-β-lactamase 1 (NDM-1) enzyme leads to multidrug resistance and has been detected from bacteria in many countries. The study was done To detect bacteria carrying blaNDM-1 gene from intensive care unit (ICU) patients and correlate the change with increasing duration of ICU stay. METHODS:- Blood and urine samples were collected from 140 patients thrice- 0-2 days, 3-7 days and 7 days of ICU admission. All bacterial isolates resistant to meropenem were evaluated for Metallo-β-lactamase (MBL) production. blaNDM-1 gene was detected using Real Time PCR from the MBLproducers. RESULT:- Overall, 458 samples (229 each) of blood and urine were collected and 75 gram negative bacteria were isolated. From these, 46.7% (35/75) strains were found to be carbapenem resistant and blaNDM-1 gene was detected in 17.3% (13/75). CONCLUSION:- High prevalence of bacteria carrying blaNDM-1 gene was seen in ICU patients increasing the burden on healthcare.
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Keywords
Carbapenemresistance, Metallo-β-lactamaseproducers, NDM-1producers, blaNDM-1gene, ICUinfections
Citation
Sud Anuj, Sharma Swati, Uppal Beena . Blandm-1 Gene Carriage In The Icu Of Tertiary Care Hospital In North India. International Journal of Scientific Research. 2017 Feb; 8(2): 7-10