Unveiling The Role Of Shh From Embryogenesis To Its Reactivation In Tumorigenesis:A Maxillofacial Perspective.
Loading...
Date
2019-04
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
World Wide Journals
Abstract
Sonic Hedgehog gene (SHH) plays a vital role in embryogenesis through its secreted protein sonic hedgehog protein (Shh). During embryogenesis, Shh acts as a morphogen controlling proximal and distant signaling in the specific development of tissue lineages, patterning, regulation of cell proliferation and suppression of tissue apoptosis. Shh also exerts its role in odontogenesis by determining the site of tooth bud formation, in tooth morphogenesis and root formation. The difference in the specific development of a region by Shh can be explained by its [a] 'Spatial gradient [b] the 'form' [c] Concentration gradient and [d] Temporal gradient. Shh signaling pathway has an extracellular and an intracellular component. A disruption of Shh pathway contributes to tumorigenesis of several cell types including those arising from odontogenic structures. This article reviews Shh from its formation in embryonic stages, its role in development and odontogenesis, to its reactivation in tumorigenesis and in specific to odontogenic pathologies.
Description
Keywords
Shh signaling, embryogenesis, Odontogenesis, tumorigenesis, Ptch mutation, odontogenic keratocyst, Nevoid Basal cell carcinoma.
Citation
Soman Cristalle. A Study Of Left Atrial Area And Volume On Echocardiography Among Atrial Fibrillation Cases With Various Aetiology. International Journal of Scientific Research. 2019 Apr; 8(4): 32-35