Cancer Stem Cell In Glioblastoma Multiforme
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Date
2017-07
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Era's Lucknow Medical College and Hospital
Abstract
Glioblastoma multiforme (GBM) is an aggressive tumor that typically exhibits treatment failure with high mortality rates, is associated with the presence of cancer stem cells (CSCs) within the tumor. CSCs possess the ability for perpetual self-renewal and proliferation, producing downstream progenitor cells that drive tumor growth. Studies of many cancer types, have identified CSCs using specific markers, but it is still unclear as to where in the stem cell hierarchy these markers fall. This review examines the current knowledge on the CSCs markers SALL4, OCT-4, SOX2, STAT3, NANOG, c-Myc, KLF4, CD133, CD44, nestin, and glial fibrillary acidic protein, specifically focusing on their use and validity in GBM research and how they may be utilized for investigations into GBMs cancer biology.
Description
Keywords
Glioblastoma multiforme, Cancer stem cells (CSCs), CSCs markers, Cancer biology.
Citation
Lal Bachchu. Cancer Stem Cell In Glioblastoma Multiforme. Era's Journal of Medical Research. 2017 Jul-Dec; 4(2): 146-159