Glp-1 Receptor Activation-based Therapy; A Promising Strategy Against Ischemic Stroke

Hyperglycemia and insulin resistance resulted from uncontrolled diabetes mellitus (DM) had has been consistently associated with poor clinical outcome in patient with ischemic stroke. Hence, early diagnosis of DM, efficient glycemic control, and prevention of its complications, together using credible therapeutic approaches, are essential to avoid the stroke complications and minimize its financial burden. Candidate strategies used to control glycaemia failed to show an efficacy in stroke patients. Glucagon like peptide-1 (GLP-1) receptor agonists are novel antidiabetic agents with a proved neuroprotection effect. Herewith, we review the concept of GLP-1 use as a neuroprotective approach against DM-associated stroke.

Keywords

Ischemic stroke; diabetes mellitus; Glucagon-like peptide 1; neuroprotection

Citation

Mohammed Shaban Fathy Kamel, Hail Moza Al, Rouf Pallivalapilla Abdul, Kassem Wessam El, Alkinidi Fahad, Kazmi Syed Mustafa. Glp-1 Receptor Activation-based Therapy; A Promising Strategy Against Ischemic Stroke. Era's Journal of Medical Research. 2018 Jan-Jun; 5(1): 32-37

URI

https://imsear.searo.who.int/handle/123456789/183995

Collections

Era's Journal of Medical Research

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