Correlation with VEGF Level for Clinical Improvement in Buerger's Disease Patients after Illizarov Surgery
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Date
2016-01
Journal Title
Journal ISSN
Volume Title
Publisher
Era's Lucknow Medical College and Hospital
Abstract
Buerger's disease also called thromboangiitis obliterans (TAO), is widely recognized as a specific disease characterized by onset of distal extremity ischemic symptoms at early age in absence of an underlying proximal embolic source, trauma, autoimmune disease, diabetes, or hyperlipidemia.1The disease is far more prevalent in the middle, near, and far east regions than in North America.2 It occurs predominantly in men, but recent evidence indicates that the incidence rate in women is increasing.3Treatment of Buerger's disease is primarily medical.Surgical treatment in non responders to medical management including lumbar sympathectomy has been tried without promising result. Various orthopaedic procedures have been tested in various studies for the treatment of peripheral vascular diseases with variable successes.We have used Ilizarov surgery to distract and then compress to produce stimulus for angiogenesis.Vascular Endothelial Factor (VEGF) is an angiogenic factor which stimulates endothelial cell growth, angiogenesis and capillary permeability.4 In this study we have measured the clinical improvement parameters and VEGF level after ilizarov procedure in peripheral arterial vascular disease.
Description
Keywords
Buerger's disease, Autoimmune disease, Ilizarov surgery, VEGF
Citation
Kumar Shailendra, Kumar Ambrish, Mishra Archna. Correlation with VEGF Level for Clinical Improvement in Buerger's Disease Patients after Illizarov Surgery. Era's Journal of Medical Research. 2016 Jan-Jun; 3(1): 1-4