Histocytoarchitectural Changes of Wistar Rat’s Kidney Exposed to Young Coconut Water Before and After Induction with Carbon Tetrachloride.
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Date
2017-01
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Abstract
Background: Young coconut water (YCW) has been used by individuals to
boast immunity and that of the experimental animals. In this study an
attempt was made to investigate the protective effect of YCW against the
Carbon tetrachloride (CCl4) induced renal toxicity in rats. Methods: A total
of 20 male adult wistar rats which were not previously subjected to any
experiment were divided into four groups. Each group has five rats.
Group 1 (Normal control) received basal diet, olive oil and water. Group 2
(Positive control) received basal diet, olive oil and YCW (100ml/kg).
Group 3 (Negative control) received basal diet, water and CCl4 diluted
with water and olive oil. Group 4 (Experimental group) received basal
diet and YCW (100ml/kg) and then intoxicated with CCl4 diluted with
water and olive oil. After day 7, the rats were sacrificed and their kidneys
were collected and processed histologically following standard protocols.
Results: Group 1 (Normal control) displayed normal histocyto-archetature
of the kidney. Group 2 (Positive control) revealed hyperplasia with mild
inflammatory response. Group 3 (Negative control) showed hypercellularity,
mild cystic spaces, necrosis, and loose glomerular membrane
indicative of high inflammatory response. Group 4 (Experimental group)
revealed moderate cellular activities in line with moderate inflammatory
response. Conclusion: The administration of YCW on the rat before
intoxication with CCl4 suppresses the deleterious effect of CCl4 on the
experimental group.
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Keywords
Kidney, coconut water, carbon tetrachloride
Citation
Jervas Ekezie, IhebuzoNdubuka Gideon, Wilson Okafor Chimaobi, Chidi Iwuji Samuel. Histocytoarchitectural Changes of Wistar Rat’s Kidney Exposed to Young Coconut Water Before and After Induction with Carbon Tetrachloride. Academia Anatomica International. 2017 Jan-June; 3(1): 44-48.