Ultraviolet A1 phototherapy: One center’s experience.
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Date
2017-01
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Abstract
Background: Ultraviolet A1(UVA1) phototherapy is increasingly being used in the treatment
of morphea, atopic dermatitis, lupus and some other recalcitrant dermatoses. We present
a retrospective review of our experience with this modality. Aim: To evaluate the treatment
response rates for various dermatoses and adverse effects of UVA1 phototherapy.
Methods: We reviewed phototherapy notes along with electronic and/or paper case records
for all patients treated with UVA1 phototherapy from October 1996 to December 2008.
Results: A total of 269 patients (outcomes available for 247) had 361 treatment courses
(treatment data available for 317 courses) over this period. We found phototherapy to be
benefi cial in 28 (53%) of 53 patients with atopic dermatitis and 19 (51%) of 37 patients
with morphea. A benefi cial outcome was recorded in all six (100%) cases of urticaria and
six (85.7%) of seven patients treated for a polymorphic light eruption. Benefi t was also
recorded in systemic lupus erythematosus (8 (44.4%) of 18), lichen sclerosus (6 (42.9%)
of 14), mastocytosis (2 (33.3%) of 6), necrobiosis lipoidica (4 (30.8%) of 13), granuloma
annulare (2 (25%) of 8), scleroderma (2 (22.2%) of 9) and keloids (1 (7.7%) of 13). Overall,
treatment was well tolerated with no patients having to stop treatment due to adverse effects.
Limitations: This is a retrospective study with no control group. Subjective/recall bias is
quite possible as a number of patients were followed up over the phone. Conclusions: Our
data suggest that ultraviolet A1 can be considered for the treatment of selected dermatoses.
However, long-term malignancy risk is as yet unknown.
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Keywords
Atopic dermatitis, morphea, phototherapy, ultraviolet A1
Citation
Attili Sasi Kiran, Dawe Robert S, Ibbotson Sally H. Ultraviolet A1 phototherapy: One center’s experience. Indian Journal of Dermatology, Venereology and Leprology. 2017 Jan-Feb; 83(1): 60-65.