Pyoderma gangrenosum: A clinico-epidemiological study.
Loading...
Date
2017-01
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Background: Pyoderma gangrenosum is a neutrophilic dermatosis of unknown etiology,
with inconstant systemic associations and a variable prognosis. Aims: To study the clinical
features and systemic associations of pyoderma gangrenosum and its response to treatment.
Methods: All patients diagnosed to have pyoderma gangrenosum at the dermatology
department of the Government Medical College, Kozhikode, from January 01, 2005 to
December 31, 2014 were included in this prospective study. Results: During the 10-year
study period, 61 patients were diagnosed to have pyoderma gangrenosum. A male predilection
was noted. The most common clinical type was ulcerative pyoderma gangrenosum (90.2%).
More than 60% of patients had lesions confi ned to the legs; 78.7% had a single lesion and
27.9% had systemic associations. Most patients required systemic steroids. Patients with
disease resistant to steroid therapy were treated with intravenous immunoglobulin G and
split-thickness skin grafts under immunosuppression induced by dexamethasone pulse
therapy. All except one patient attained complete disease resolution. Limitations: The
main limitation of our study was the small sample size. Conclusions: The male predilection
documented by us was contrary to most previous studies. We found split-thickness skin graft
to be a useful option in resistant cases. More prospective studies may enable the formulation
of better diagnostic criteria for pyoderma gangrenosum and improve its management.
Description
Keywords
Dexamethasone pulse therapy, intravenous immunoglobulin G, pyoderma gangrenosum, systemic association
Citation
Riyaz Najeeba, Mary Vineetha, Sasidharanpillai Sarita, Roshin Riyaz A, Snigdha Ottakandathil, Latheef Ettappurath N Abdul, Rahima Saleem, Bindu Valiaveetil, Anupama Ravindran N, Sureshan Deepthi N, Sherjeena Pentam Veil Beegum. Pyoderma gangrenosum: A clinico-epidemiological study. Indian Journal of Dermatology, Venereology and Leprology. 2017 Jan-Feb; 83(1): 33-39.