Estimation of serum lactate dehydrogenase in smokeless tobacco consumers.
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Date
2016-11
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Abstract
Statement of Problem: Salivary and serum lactate dehydrogenase (LDH) levels have been
correlated with potentially malignant lesions. Salivary LDH levels require special testing and
can be expensive. The need for a simple and cost‑effective analysis tool is essential to detect
the oral malignant lesions to benefit rural populations.
Aim: The aim of this study is to estimate the serum LDH in patients with oral lesions due to
the consumption of smokeless tobacco.
Materials and Methods: Thirty‑five patients with lesions were selected for this study while
twenty patients served as a control. Levels of serum LDH were assessed. Age‑ and sex‑matched
controls (n = 10) with no smokeless consumption habit and with the habit but without
lesion (n = 10) also had their blood drawn to assess the basal level of LDH. The results were then
analyzed through the two‑tailed t‑test and Chi‑square analysis using the SPSS statistics software.
Results: The mean LDH value of patients with habit and lesion is 446.8 U/L; the mean LDH
value for patients with habit but without the presence of a lesion is 421.2 U/L, and the mean
LDH value for patients without a habit or lesion is 269.4 U/L. The patients having the habit of
using smokeless tobacco had higher LDH values compared to the other two groups, and it is
found to be statistically significant (p < 0.05).
Conclusion: Serum LDH values increased in patients with the habit of chewing smokeless
tobacco.
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Keywords
Oral lesions, serum lactate dehydrogenase, serum marker
Citation
Chari Abinaya, Rajesh P, Prabhu S. Estimation of serum lactate dehydrogenase in smokeless tobacco consumers. Indian Journal of Dental Research. 2016 Nov-Dec; 27(6): 602-608.