High-risk Hypertension and Its Clinical Implications.
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Date
2014-11
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Abstract
Hypertension (HT) is a well-established risk factor for cardiovascular disease (CVD) and chronic kidney disease (CKD). Only
<50% of treated hypertensive patients have a BP of <140/90 mmHg, which is a cause for much concern. These treated but
inadequately controlled hypertensive patients are at significant risk for developing CVD and other complications. Telmisartan
is a long-acting angiotensin receptor blocker (ARB), which has multiple positive effects aside from its antihypertensive efficacy.
It reduces CV events in high-risk patients, has favorable effects on endothelial function including renoprotective effects. Trials
like the MAPHY and BCAP have shown that β blockers (metoprolol) have beneficial effects on outcomes and survival along
with reduction in BP. Most hypertensives need combination approach to control their high BP. Being cardioprotective drugs,
combination of telmisartan and metoprolol is beneficial for secondary prevention of cardiovascular events in high-risk patients
with HT.
Description
Keywords
Hypertension, renoprotective, combination, cardioprotective
Citation
Ram C Venkata S, Aggarwal K K. High-risk Hypertension and Its Clinical Implications. Indian Journal of Clinical Practice. 2014 Nov; 25(6): 522-526.