A Comparative Study Between Cleavage Stage Embryo Transfer at Day 3 and Blastocyst Stage Transfer at Day 5 in IVF/ICSI on Clinical Pregnancy Rates.
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Date
2013-12
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Abstract
Objective: To evaluate the efficacy of blastocyst transfer in comparison with cleavage stage transfer. Study design: A
randomized, prospective study was conducted in Infertility Clinic, Dept. of Obstetrics and Gynecology, Mahatma Gandhi
Hospital, Jaipur on 300 patients aged 25-40 years undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/
ICSI) cycle from May 2010 to April 2011. When three or more Grade I embryos were observed on Day 2 of culture, patients
were divided randomly into two study groups, cleavage stage transfer and blastocyst transfer group having 150 patients
each. Primary outcomes evaluated were, clinical pregnancy rate and implantation rate. The results were analyzed using
proportions, standard deviation and Chi-square test. Results: Both the groups were similar for age, indication and number of
embryos transferred. Clinical pregnancies after blastocyst transfer were significantly higher 66 (44.0%) compared to cleavage
stage embryo transfer 44 (29.33%) (p < 0.01). Implantation rate for blastocyst transfer group was also significantly higher
(p < 0.001). Conclusion: Blastocyst transfer having higher implantation rate and clinical pregnancy rate leads to reduction in
multiple pregnancies.
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Keywords
Blastocyst transfer, embryo transfer, in vitro fertilization, clinical pregnancy rates, intracystoplasmic sperm injection
Citation
Kaur P, Swarankar M L, Maheshwari M, Acharya V. A Comparative Study Between Cleavage Stage Embryo Transfer at Day 3 and Blastocyst Stage Transfer at Day 5 in IVF/ICSI on Clinical Pregnancy Rates. Indian Journal of Clinical Practice. 2013 Dec; 24(7): 663-667.