Structural Correlates of Depressive Symptoms in Prodromal Alzheimer’s Disease.
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Date
2016
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Abstract
Background/Aims: We conducted a cross-sectional study to investigate the structural magnetic resonance imaging correlates of depressive symptoms at the initial clinical stages of Alzheimer’s disease (AD).
Methods: Subjects aged 65 or more were categorized as prodromal AD (n=18), mild AD (n=35), or normal cognition (n=76). Depressive symptoms were measured by means of the 15-item abridged version of the Geriatric Depression Scale. Potential gray matter correlates of depressive symptoms were analyzed using the Statistical Parametric Mapping software package.
Results: Significant results were obtained in the prodromal AD group only. In that group, depressive symptoms were related to atrophy in the left precentral gyrus (Brodmann area 6) (p≤0.01, FWE corrected).
Conclusion: Our results, added to the existing literature, suggest that dysfunction in left-sided, cognitively and functionally salient, cortical regions along with relative preservation of deficit awareness, provided by the right hemisphere, explain depressive symptoms in the initial clinical stages of AD.
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Keywords
Alzheimer’s disease, depression, magnetic resonance imaging, structural correlates
Citation
Olazarán Javier, García-Polo Pablo, García-Frank Daniel, Quirós Alicia, Hernández-Tamames Juan Antonio, Acedo Carmen, Álvarez-Linera Juan, Frank Ana. Structural Correlates of Depressive Symptoms in Prodromal Alzheimer’s Disease. British Journal of Medicine and Medical Research. 2016; 14(4): 1-10.