Effects of Methotrexate on Ovary: An Experimental Study on Albino Rat.
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Date
2016-01
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Abstract
Background: Methotrexate is an anti-cancer drug but carries toxic effects
on genital system and the study was conducted to find out the exact
mechanism involved and to search for remedy. Methods: Twelve female
albino rats 6 experimental and 6 control received methotrexate. [in former]
and normal saline. [in latter], 1 mg/kg, intraperitoneally for 6 weeks.
Results: H/E stained sections from ovary of experimental rat showed
poorly developed Graafian follicles with loss of ova. There were follicular
spaces in these rats with albuminous fluid and inflammatory cells. Granulosa
lutein cells also showed degeneration due to inflammation. Cells were found
to be smaller, shrunken, and irregular with vacuolated lighter colour
cytoplasm. Conclusion: The drug is safer to be used in those patients who
have completed their family.
Description
Keywords
Methotrexate, Ovary, Female Rat, Histopathology
Citation
Battan Gulshan, Tandon Rati, Vasenwala Shaista M, Faruqi Nafis Ahmad. Effects of Methotrexate on Ovary: An Experimental Study on Albino Rat. Academia Anatomica International. 2016 Jan-June; 2(1): 24-27.