Prevalence and Susceptibility Profiles of Nonfermentative Gram-negative Bacilli Infection in a Tertiary Care Hospital of Eastern India.
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Date
2013-10
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Abstract
Background: Nonfermentative gram-negative bacilli (NFGB) have emerged as a major cause of nosocomial infections.This study
was undertaken to know the prevalence of nonfermenters isolated from different clinical samples along with their susceptibility
profile. Material and methods: Conventional bacteriological methods were used for identification and susceptibility testing of
nonfermenters. Susceptibility testing was performed by methods as recommended by Clinical Laboratory Standard Institute
(CLSI). Results: Out of the total 1,650 clinical samples received NFGB were found in 201 samples with an isolation rate of
12.18%. Nonfermenters isolated were Pseudomonas aeruginosa (50.24%), Acinetobacter baumannii (24.87%), Acinetobacter lowffii
(5.47%), Pseudomonas fluorescens (1.49%), Pseudomonas stutzeri (1.99%), Burkholderia cepacia (6.96%), Stenotrophomonas maltophilia
(2.98%), Achromobacter xylosoxidan (3.98%) and Shewanella putrefaciens (1.99%). Most of the isolated organisms were multidrugresistant
(MDR). P. aerurginosa showed good sensitivity to imipenem (91.08%), cefoperazone sulbactum (68.31%) combination,
amikacin (69.30%) and colistin (100%). A. baumannii showed 90% sensitivity to imipenem and 94% to colistin. Conclusion: Our
study showed that prevalence of NFGB amongst different clinical isolates is significantly high especially in this part of the
world and these organisms are often MDR. In this scenario, we propose all laboratory samples should be screened for NFGB
even in clinically unsuspected cases. P. aeruginosa showed good sensitivity to colistin, imipenem, amikacin and cefoperazone
sulbactum combination while A. baumannii showed good sensitivity to imipenem and colistin.
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Keywords
Nonfermentative gram-negative bacilli, prevalence, Pseudomonas aeruginosa, Acinetobacter baumannii, nosocomial infection
Citation
Rit Kalidas, Nag Falguni, Raj Hirak Jyoti, Maity P K. Prevalence and Susceptibility Profiles of Nonfermentative Gram-negative Bacilli Infection in a Tertiary Care Hospital of Eastern India. Indian Journal of Clinical Practice. 2013 Oct; 24(5): 451-455.