Dexmedetomidine and Anesthesia.
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Date
2013-08
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Abstract
The α2-adrenoceptors (ARs) by virtue of their sedative, analgesic, sympatholytic, anesthetic-sparing and hemodynamicstabilizing
properties, have been used as an adjunct to local anesthetics for prolongation of effect. Dexmedetomidine a
stereoisomer of medetomidine a highly selective α2-adrenergic receptor (AR) agonist with a relatively high ratio of α2/ α1-activity
(1620:1 as compared to 220:1 for clonidine). It has recently been introduced in anesthesia practice. It is currently being
used for continuous intravenous sedation in the intensive care setting and procedural sedation in nonintubated patients.
Description
Keywords
Dexmedetomidine, α2-2 adrenergic receptor agonist, adjuvant, analgesic
Citation
Sharma Sudivya, Jain Prashast. Dexmedetomidine and Anesthesia. Indian Journal of Clinical Practice. 2013 Aug; 24(3): 223-225.