Study of Antioxidant Enzymes, MDA and Lipid Profile in Cerebral Malaria.
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Date
2013-05
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Abstract
Cerebral malaria (CM) is the most important complication of falciparum malaria. However, its pathophysiology is not
understood. Malaria infection is accompanied by increased production of reactive oxygen species (ROS) and the malaria
parasites are sensitive to oxidative damage. So, we conducted a case-control study to estimate antioxidant activity, lipid
peroxidation in 36 patients with CM. In present study, catalase (CAT), reduced glutathione (GSH) and lipid peroxidation product
malondialdehyde (MDA) were increased significantly and superoxide dismutase (SOD) was decreased significantly in CM
patients at the time of admission with respect to control group. After treatment, SOD activity was increased and MDA level was
decreased; rest of the parameters did not show any significant change. So, the antioxidant enzyme has a prognostic role in CM.
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Keywords
Cerebral malaria, catalase, reduced glutathione, superoxide dismutase, malondialdehyde
Citation
Tyagi A, Tyagi R, Vekariya R, Ahuja A. Study of Antioxidant Enzymes, MDA and Lipid Profile in Cerebral Malaria. Indian Journal of Clinical Practice. 2013 May; 23(12): 823-825.