In vivo effects of isatin on certain enzymes, lipids & serotonergic system of rat brain.

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Date
1994-11-01
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Abstract
Isatin (10 microM) strongly inhibited the activity of rat brain monoamine oxidase-B (MAO-B) in vitro. At millimolar concentrations (1-10 mM) it inhibited brain acetylcholinesterase (AChE) and sodium, potassium-adenosine triphosphatase (Na+, K(+)-ATPase) activity also. However, isatin did not affect these enzymes after both acute and chronic treatments in vivo. Administration of isatin to rats at 300 mg/kg body weight for 2 and 6 h significantly raised brain serotonin levels. Chronic treatment for 20 days resulted in enhanced brain glycolipids and plasmalogen levels. There was no change in the levels of 5-hydroxy indole acetic acid (5 HIAA), phospholipids, cholesterol and gangliosides under these conditions.
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Kumar R, Bansal RC, Mahmood A. In vivo effects of isatin on certain enzymes, lipids & serotonergic system of rat brain. Indian Journal of Medical Research. 1994 Nov; 100(): 246-50
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https://imsear.searo.who.int/handle/123456789/18242
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Indian Journal of Medical Research