Efficacy and Tolerability of Trandolapril in Mildto- moderate Hypertension: A Double-blind Comparison with Enalapril.
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Date
2012-07
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Abstract
Objective: To compare the efficacy and tolerability between trandolapril and enalapril in mild-to-moderate hypertension.
Material and Methods: This was a prospective, double-blind, parallel, comparative clinical trial involving 120 patients
with mild-to-moderate hypertension. Patients were randomized to receive trandolapril 2-4 mg once-daily and enalapril
5-10 mg once-daily. The participants were followed for eight weeks. Results: Both the drugs achieved effective control of
blood pressure (BP) at the end of eight weeks. The mean reduction in systolic BP (SBP) was 22.17 mmHg with trandolapril
and 21.47 mmHg with enalapril group; the mean reduction of diastolic BP (DBP) was 9.57 mmHg with trandolapril and
11.13 mmHg with enalapril. Adverse events developed in 11 (18.3%) and 12 (20%) patients in trandolapril and enalapril
group, respectively. Conclusion: The efficacy and tolerability of trandolapril was comparable to enalapril in mild-to-moderate
hypertension with minor adverse events.
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Keywords
Hypertension, ACEIs, trandolapril, enalapril
Citation
Jyothi R, Pundarikaksha H P, Prabhu N C Srinivasa, Girish K, Vasundhara K. Efficacy and Tolerability of Trandolapril in Mildto- moderate Hypertension: A Double-blind Comparison with Enalapril. Indian Journal of Clinical Practice. 2012 July; 23(2): 86-91.