A Study of Clinical Profile of 50 Patients with Portal Hypertension and to Evaluate Role of Noninvasive Predictor of Esophageal Varices.
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Date
2012-02
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Abstract
Objective: To study the predictive power of noninvasive investigative parameters (clinical, biochemical, radiological) for
detection of esophageal varices in patients with portal hypertension (PHT) as compared to invasive parameters (upper
gastrointestinal endoscopy). Materials and methods: Fifty patients with PHT, between May 2008 to September 2010, were
studied. Those who had decompensated liver diseases, HIV, hepatocellular carcinoma, metastasis in liver, parentral drug
addiction, chronic febrile illness, H/O treatment taken for PHT in the form of surgery or endoscopic bending or sclerotherapy
were excluded. Detailed clinical history was taken and physical examination was done. All patients underwent the required
hematological, biochemical, radiological, endoscopic and histopathological investigations. Results: Platelet count/splenic size
showed a significant correlation between presence or absence and grade of esophageal varices (p < 0.00015). If a cut-off value
of 1,000/cu mm is taken, then 87.5% (35/40) patients with esophageal varices have ratio <1,000 while 20% (2/10) of patients
with ratio <1,000 did not have any varices. It was also observed that lower the ratio, higher the grade of varices. Conclusion:
Asymptomatic esophageal varices, which is quite common, can be easily diagnosed with invasive endoscopy or otherwise can
be suspected with noninvasive predictors like platelet/spleen size ratio in our country, where financial constraint is a major
problem for investigations like endoscopy.
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Keywords
Portal hypertension, noninvasive predictors, asymptomatic esophageal varices, platelet/spleen size ratio
Citation
Kaji B C, Bhavsar Yagnesh R, Patel Nitin, Garg Anupam, Kevadiya Hiren, Mansuri Zishan. A Study of Clinical Profile of 50 Patients with Portal Hypertension and to Evaluate Role of Noninvasive Predictor of Esophageal Varices. Indian Journal of Clinical Practice. 2012 Feb; 22(9): 454-457.