Association between the p53 codon 72 polymorphism and primary open‑angle glaucoma risk: Meta‑analysis based on 11 case–control studies.
Loading...
Date
2016-10
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The TP53 is important in functions of cell cycle control, apoptosis, and maintenance of DNA integrity.
Studies on the association between p53 codon 72 polymorphism and primary open‑angle glaucoma (POAG)
risk have yielded conflicting results. Published literature from PubMed and Web of Science databases
was retrieved. All studies evaluating the association between p53 codon 72 polymorphisms and POAG
were included. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated. Eleven separate
studies including 2541 cases and 1844 controls were pooled in the meta‑analysis. We did not detect a
significant association between POAG risk and p53 codon 72 polymorphism overall population except
allele genetic model (C vs. G: OR = 0.961, 95% CI = 0.961–0.820, P = 0.622). In the stratified analysis for
Asians and Caucasians, there was an association between p53 codon 72 polymorphism and POAG. In the
dominant model in the overall population and by ethnicity subgroups, the highest elevated POAG risk
was presented. In summary, these results indicate that p53 codon 72 polymorphism is likely an important
genetic factor contributing to susceptibility of POAG. However, more case–controls studies based on larger
sample size and stratified by ethnicity are suggested to further clarify the relationship between p53 codon
72 polymorphism and POAG.
Description
Keywords
Codon 72, meta‑analysis, p53, polymorphism, primary open‑angle glaucoma
Citation
Gohari Mohsen, Neámatzadeh Hossein, Jafari Mohammad Ali, Mazaheri Mahta, Zare-Shehneh Masoud, Abbasi-Shavazi Elahe. Association between the p53 codon 72 polymorphism and primary open‑angle glaucoma risk: Meta‑analysis based on 11 case–control studies. Indian Journal of Ophthalmology. 2016 Oct; 64(10): 756-761.