Effect of Combined Aerobic and Anaerobic Training on Hemodynamic Response, Serum Oxidative Stress Markers and Platelet ATP Synthase Activities in Patients with Coronary Heart Disease: A Pilot Study.
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Date
2015
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Abstract
Background: The overall aim of this work was to study the impact of combined aerobic and
anaerobic training in relation to hemodynamic response (heart rate, systolic blood pressure, and
double product), serum oxidative stress markers (lipoperoxides, nitrites-nitrates) and platelet ATP
synthase activities in patients with coronary heart disease.
Materials and Methods: Ten subjects, 9 male and 1 female, (mean age 57.7±7.2 years) with
coronary heart disease participated in this study. Patients performed combined aerobic and
anaerobic exercise for 24 sessions (three times a week).
Results: The results suggest myocardium adaptations, manifested in the reduction of heart rate
with increased workloads and increased double product [(heart rate) x (systolic blood pressure)]
according to the intensity, frequency and duration of training. The ATP synthesis rate was
significantly increased at session 3 (post-exercise) compared to session 1 (pre exercise).
Furthermore, rate of ATP hydrolysis was significantly decreased at session 24 (post-exercise 3)
compared to session 1 (post-exercise 1). Serum lipid peroxidation products and nitric oxide
catabolites were significantly diminished at session 24 (pre-exercise).
Conclusion: In some patients hemodynamic responses showed improvements in response to
exercise. The exercise sessions induced lower levels of lipid peroxidation products, nitric oxide
catabolites and ATPase activity. Conversely, ATP synthase activity showed higher values at the
end of the experiment. These results confirm the beneficial effect of combined aerobic and
anaerobic exercise.
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Keywords
Coronary heart disease, ATP synthase, oxidative stress, anaerobic exercise
Citation
Villarruel-Sahagún José A, Ortiz Genaro G, Pacheco-Moisés Fermín P, Martínez-Cano Evelia, Gómez Salvador G, Gaxiola-López Efraín, Marín-Pineda Gustavo, Fajardo Pedro G., González-Renovato Erika D, Sánchez-Luna Sergio A, Alatorre-Jiménez Moisés A, Cortés-Enríquez Fernando, Sánchez-Luna Juan P. Effect of Combined Aerobic and Anaerobic Training on Hemodynamic Response, Serum Oxidative Stress Markers and Platelet ATP Synthase Activities in Patients with Coronary Heart Disease: A Pilot Study. British Journal of Medicine and Medical Research. 2015; 8(11): 993-1002.