Relation of cerebrospinal fluid/plasma HIV-RNA discordance with neurocognitive impairment.
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Date
2015-09
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Abstract
Neurological involvement is common in patients infected with
HIV. The effectiveness of antiretroviral drugs in lowering the
levels of HIV-RNA in cerebrospinal fluid (CSF) is limited by
their inability to cross the blood–brain barrier. Discordance in
CSF/plasma HIV-RNA levels may have a bearing on the
progression of neurological disease in these patients. We report
a woman with subacute neurocognitive impairment and abnormal
findings on brain MRI, in whom there was a discordance
between CSF/plasma HIV-RNA levels. The patient improved
after a change in her highly active antiretroviral therapy
(HAART) regimen. We also reviewed the available literature on
the subject and found seven articles describing 27 patients.
Natl Med J India 2015;28:228–32
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Cárdenas Graciela, López-González M., Monzón-Falconi J.F., Perales-Martínez D., López-Vejar C., Soto-Hernández J.L. Relation of cerebrospinal fluid/plasma HIV-RNA discordance with neurocognitive impairment.National Medical Journal of India. 2015 Sept-Oct; 28(5): 228-232.