Role of Wnt-p53-Nox Signaling Pathway in Cancer Development and Progression.
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Date
2015
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Abstract
Signaling pathways play an intricate role in regulating the homeostasis of a normal cell and any
chronically altered activity in such signaling pathways causes cancer. Such aberrantly activated
Wnt and vanished p53 signaling contribute to the development of various carcinomas. Majority of
cancer cells exhibit elevated production of reactive oxygen species (ROS) in an NADPH oxidases
dependent manner that further enhances cellular damage. However, Nox family enzymes regulate
various physiological functions; for instance, gene regulation, cellular signaling, host defense and
cell differentiation. All of these processes get affected in cancer thereby signifying the role of Nox
in controlling various signaling pathways such as Wnt and p53. Therefore, unraveling of complex
signaling pathways underlying tumorigenesis is enforcing the development of next-generation
anticancer drugs directed against specific molecular targets.
This review provides an insight about Nox in regulation of Wnt and p53 pathway to govern the
pathogenesis of cancer. Therefore, implementation of NOX inhibitors for inhibiting aberrant Wnt
and p53 signaling could provide novel opportunities for therapeutic intervention.
Description
Keywords
Signaling, cancer, NOX, ROS, Wnt, p53, pathogenesis, therapeutics
Citation
Kumar Dhiraj, Sharma Sakshi, Verma Sagar, Kumar Pravir, Ambasta Rashmi Kumar. Role of Wnt-p53-Nox Signaling Pathway in Cancer Development and Progression. British Journal of Medicine and Medical Research. 2015; 8(8): 651-676.