Vitamin D Receptor fok I Gene Polymorphism in Angiographically Proven Coronary Artery Disease Subjects: Case - Control Study.
Loading...
Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Aims: Coronary artery disease (CAD) is multifactorial disease resulting from modifiable and non
modifiable risk factors. Gene polymorphism is one of the non modifiable risk factors, which may
contribute to disease susceptibility. Identifying genetic polymorphisms is essential for better
understanding of pathophysiology and treatment strategies for a particular disease. The objective
of our study was to evaluate the association of vitamin D receptor (VDR) fok I polymorphism with
CAD. .
Place and Duration of the Study: The study samples were collected at Narayana Medical
College Hospital, Nellore and genetic analysis done at Sri Ramachandra University, Chennai,
India, from Nov 2013 to June 2014.
Materials and Methodology: The study included 40 angiographically proven CAD subjects as cases and 40 normal healthy controls .VDR fok I polymorphism was analysed by PCR-RFLP
method. Chi Square and odds ratio was used to find the association.
Results: F allele frequency is 66.25% in CAD vs 52.5% in controls. There is no significant
association of FF (p= 0.099), Ff (p= 0.851), ff (p= 0.138) with CAD.
Conclusion: There is no significant association of VDR fok I polymorphism with CAD in south
Indian population. According to our study F allele frequency is more in CAD than in controls.
Description
Keywords
Coronary artery disease, vitamin D receptor, fok I, South Indian
Citation
Sowjanya B, Selvi Vettri, Suneel B, Balakrishna D, Kumar D R Nagendra, Krishna B Phani, Naidu J N. Vitamin D Receptor fok I Gene Polymorphism in Angiographically Proven Coronary Artery Disease Subjects: Case - Control Study. British Journal of Medicine and Medical Research. 2015; 8(7): 612-617.