Synthetic Bone Substitutes in Combination with Growth Factors for Maxillary Sinus Floor Augmentation: A Mini-review.
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Date
2015
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Abstract
Objective: Growth factors have been applied in maxillary sinus augmentation with clinically
successful results. The purpose of this article is to evaluate the effectiveness of growth factors in
combination with various synthetic scaffolds. Methods and Materials: A systematic review of studies examining the effects of synthetic
materials in combination with growth factors were performed.
Results: Twelve (1 human and 11 animal) studies were eligible for inclusion. Due to the great
heterogeneity of the studies regarding design, materials and outcomes, a meta-analysis was not
performed. The majority of the studies show a reduction in healing time and enhancement of bone
formation within the subantral environment. Bone Morphogenetic Protein-2 and GDF-5 were the
two most common osteoinductive factors studied, showing a significant effect on new bone
formation. Moreover, initial outcomes of trials with stem cells genetic transformation, that results in
increased production of growth factors, are positive and justify further research.
Conclusion: The incorporation of growth factors into the synthetic scaffold may be beneficial
regarding the healing process.
Description
Keywords
Sinus augmentation, synthetic materials, PRF, growth factors
Citation
Nacopoulos Cleopatra C, Dontas Ismene, Chronopoulos Efstathios, Khaldi Lubna, Vesala Anna Maria, Triantafyllopoulos Ioannis K, Papaioannou Nikolaos. Synthetic Bone Substitutes in Combination with Growth Factors for Maxillary Sinus Floor Augmentation: A Mini-review. British Journal of Medicine and Medical Research. 2015; 7(12): 1026-1034.