Prognostic Implications of Expression of the Wilms Tumor 1 (WT1) Gene in Acute Leukemia (Experience from South Egypt).
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Date
2015
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Abstract
Background: Wilms’ tumor (WT1) gene expression has been reported in the majority of acute
leukemia patients at diagnosis and has been evaluated as a prognostic and minimal residual
disease (MRD) marker but its role is still controversial.
Methods: Real-time quantitative polymerase chain reaction was used on bone marrow samples
from 100 newly diagnosed adults and pediatrics acute leukemia patients (50 AML and 50 ALL
patients). WT1 expression were examined at diagnosis and at the end of induction.
Results: WT1 was expressed in (14%) ALL and in (36%) AML patients. We found no statistically
significant impact of WT1 expression at diagnosis on response p= 0.054, 0.057, DFS (P = 0.591,
0.858), or OS (p= 0.339, p= 0.331) in ALL and AML patients respectively. Persistence of WT1
expressions at the end of induction didn't show any effect on relapse rate in AML however, it showed significant results in ALL p=0.045.
Conclusion: Our results suggest that WT1 expression in patients with acute leukemia doesn't
have any implication on response or survival however, significant association was found in
predicting ALL relapse but the small sample size should be considered.
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Keywords
Wilms tumor gene 1, acute leukemia, real-time quantitative polymerase chain reaction
Citation
Ibrahim Abeer, Badrawy Hosny, Sayed Heba. Prognostic Implications of Expression of the Wilms Tumor 1 (WT1) Gene in Acute Leukemia (Experience from South Egypt). British Journal of Medicine and Medical Research. 2015; 7(1): 61-71.