Role of Hepatitis C Virus Infection on Lymphoproliferative Disorders after Non-liver Transplantation.
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Date
2015
Journal Title
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Abstract
Aims: The number of reports on HCV positive PTLD patients in non-liver transplantation setting as
well as our knowledge on the issue is extremely limited. In this study, we aimed to investigate the
impact of HCV infection on non-liver transplant recipients regarding PTLD development.
Study Design: The study is designed as a comprehensive review of the literature.
Place and Duration of Study: The review of the literature was performed at the Department of
Internal Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Methodology: A comprehensive search was performed for finding the available data by Pubmed
and Google scholar search engines for reports of lymphoproliferative disorders occurring in non liver
organ transplant patients with regard to their HCV test results. P value of 0.05 was considered significant.
Results: Data of overall 61 patients was entered into analysis. 9 PTLD patients were HCV positive
and the remaining were HCV negative. HCV positive patients were significantly younger at the time
of transplantation (p=0.04). The same patient group had relatively shorter time from transplantation
to PTLD development, but significant level has not been achieved (74±57 vs. 46±38, respectively;
p=0.06). No other difference was found.
Conclusion: HCV positivity can reduce the time interval between transplantation and PTLD
development which can be interpreted as HCV can enhance the rate of PTLD in non-liver transplant
recipients. Our study presents a significant evidence for HCV relationship with PTLD in non-liver
transplantation setting. Further studies with prospective designations are needed to confirm our
results.
Description
Keywords
Posttransplant lymphoproliferative disorders, PTLD, hepatitis C virus, HCV
Citation
Khedmat Hossein, Amini Mohsen, Ghamar-Chehreh Mohammad Ebrahim, Aghaei Aghdas, Agah Shahram. Role of Hepatitis C Virus Infection on Lymphoproliferative Disorders after Non-liver Transplantation. British Journal of Medicine and Medical Research. 2015; 6(9): 899-907.