Unilateral gonadoblastoma with dysgerminoma in normal fertile woman having a child: Extremely rare occurrence with characteristic immunohistomorphology.
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Date
2016-10
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Abstract
Gonadoblastomas (GBYs) are rare gonadal tumors almost always arising
from a dysgenetic gonad with a Y chromosome. Very rarely, GBYs appear in
otherwise normal women with a history of pregnancy. The typical histological
appearance of GBY can be altered by extensive deposition of basement
membrane material, calcification, or overgrowth by a malignant tumor. Less
than 10 cases have been reported with normal 46XX karyotype. Only six cases
of GBY have been described in pregnant women. We present a unique case of
GBY with dysgerminoma in a genotypically and phenotypically normal woman
with a history of normal pregnancy, absence of virilization, and characteristic
immunohistomorphological features.
Description
Keywords
Fertile woman, gonadoblastoma with dysgerminoma, gonadoblastoma with normal karyotype
Citation
Kulkarni Maithili Mandar, Khandeparkar Siddhi Gaurish Sinai, Joshi Avinash R, Bhayekar Pallavi V. Unilateral gonadoblastoma with dysgerminoma in normal fertile woman having a child: Extremely rare occurrence with characteristic immunohistomorphology. Indian Journal of Pathology & Microbiology. 2016 Oct-Dec 59(4): 527-529.