Characterization of G6PD Rohini--a new class III Indian variant.
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1992-04-01
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A new Indian G6PD variant was detected in a 15 yr old Maratha male during a population screening programme in high school children in Bombay (India). The propositus and two family members having the same variant were apparently healthy. This enzyme variant has a mild erythrocyte G6PD deficiency and a slow electrophoretic mobility. It is characterized by a high Michaelis-Menton constant for G6P, a bimodal curve for pH optima and a slight decrease in the thermostability. The rate of utilization of substrate analogue is similar to that of normal. These observations suggest identification of a new class III variant, designated as G6PD Rohini.
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Sayyed Z, Mukherjee MB, Mudera VC, Colah R, Gupte S. Characterization of G6PD Rohini--a new class III Indian variant. Indian Journal of Medical Research. 1992 Apr; 96(): 96-100