Expression of CD71 by flow cytometry in acute leukemias: More often seen in acute myeloid leukemia.
Loading...
Date
2016-07
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Background: CD71 is a marker that has been usually used for identifying
dysplasia in the erythroid series. We have tried to evaluate the expression of
CD71 in various types of acute leukemias. Materials and Methods: We studied
48 patients of acute leukemia, of which 25 were acute myeloid leukemia (AML),
13 were precursor B‑acute lymphoblastic leukemia (B‑ALL), 8 were T‑ALL,
and 2 were mixed phenotype acute leukemia (T/myeloid) as per the WHO
classification. Results: We found that the expression of CD71 was most
prevalent in AMLs (84%), followed by T‑ALL (50%) and least in B‑ALL (30%).
Conclusion: This finding clearly shows the higher expression of CD71 in
AMLs compared to other common type of leukemias, such as B‑ and T‑ALL.
We suggest that the high expression of CD71 in AMLs could be used as a
diagnostic marker and may also be used for minimal residual disease analysis
after further studies in posttreatment scenario. This study is the first of its kind
in the South Asian population.
Description
Keywords
Acute leukemia, acute lymphoblastic leukemia, acute myeloid leukemia, CD71, flow cytometry
Citation
Pande Amit, Dorwal Pranav, Jain Dharmendra, Tyagi Neetu, Mehra Simmi, Sachdev Ritesh, Raina Vimarsh. Expression of CD71 by flow cytometry in acute leukemias: More often seen in acute myeloid leukemia. Indian Journal of Pathology & Microbiology. 2016 July-Sept 59(3): 310-313.