Aspirin Resistance in Different Doses by Bleeding Time and Urinary 11-dehydro-thromboxane B2.
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Date
2016-01
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Abstract
The aim of the present study was the evaluation bleeding time (BT) in comparison to Urinary 11-dehydro
thromboxane B2 (TXB2) regarding different ASA frequent dosages used in Borujerd city. This is a double
blind randomized clinical trial on 370 subjects aged 35 years and older, referred to clinical offices in
Borujerd. All ischemic heart disease’s patients were randomly assigned to 4 ASA dose groups (80 mg, 81
mg, 100 mg and 325 mg) and one group-matched control group without any IHD. BT was measured by Ivy
method; TXB2 was measured in a urine sample, both at least 5 days after ASA consumption. Probale AR
was indicated if TXB2 was normal or higher than normal higher limit values, or BT was normal or lower than
normal higher values. (IRCT201202026958N3) Probale AR was present in 37.6% and 64% resistance by BT
and TXB2, respectively. All 4 treated groups had higher TXB2 levels than the control group/normal values
(p>0.05). Also, urinary TXB2 level correlated positively with BT. Given the simplicity and low costs of its
performance it might be of some potential use in developing countries. However, due to IVY method limitations
it cannot be perceived as a tool to assess such specific aspects of platlat function or aspirin resistance.
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Ali Maleki1 , Mostafa Cheraghi1, Scott Reza Jafarian Kerman2 , Mahdi Montazeri3 , Negin Rashidi4, Reza Ghanavati3, Saeid Foroughi5, Farshid Alyari6 and Hassan Ahmadvand7. Aspirin Resistance in Different Doses by Bleeding Time and Urinary 11-dehydro-thromboxane B2. Indian Journal of Physiology and Pharmacology. 2016 Jan-Mar; 60(1): 30-37.