Prolonged Infusion of Dexmedetomidine in Critically-ill Children.
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Date
2016-11
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Abstract
Objective: To describe main indications, doses, length of infusion and side effects related to dexmedetomidine infusion.
Methods: Observational and retrospective study evaluating dexmedetomidine use in pediatric intensive care unit.
Results: 77 children received dexmedetomidine infusion longer than 6 hours for mechanical ventilation weaning (32.5%), post- neurosurgery and post-upper airway surgery (24.7%), non-invasive ventilation (13%), refractory tachycardia (6.5%) and other causes (23.3%). After 6 hours of infusion, significant decrease in mean arterial pressure and heart rate was observed in all groups. Six children (8%) required withdrawal of drug because of possible side effects: hypotension, bradycardia and somnolence.
Conclusion: Dexmedetomidine may be used as sedative in critically ill children without much side effects.
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Keywords
Bradycardia, Hypotension, Intensive care, Sedation
Citation
Cinara Andreolio, Jefferson Pedro Piva, Elisa Baldasso, Roberta Ferlini and Rafaela Piccoli. Indian Pediatrics. 2016 Nov; 53(11): 987-989.