Differential antibrucella activity of bovine and murine macrophages.
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Date
2016-07
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Abstract
Brucella abortus is an intracellular pathogen affecting macrophages. Macrophages release some antibrucella components such as lysozymes (LZ), reactive oxygen species (ROS) and reactive nitrite intermediates (RNI) which prevent intracellular survival of Brucella. The present study compared the antibrucella activity of bovine and murine macrophages following stimulation with B. abortus lipopolysaccharides. Our results revealed increased production of these antibrucella substances in murine macrophages as compared to bovine macrophages. The differential production of these antibrucella components explained the differential B. abortus killing ability of these species (bovine and mice) that was measured in terms of intramacrophagic survival of Brucellae in murine and bovine macrophages.
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Keywords
Brucella abortus, Cell stimulation, Cytokines, Lysozymes, RNI, ROS
Citation
Akhtar͙, Raheela Khan, Iahtasham Melzer, Falk Neubauer, Heinrich Anjum, Aftab Ahmad Younus, Muhammad Aslam, Asim Imran, Sadaf. Differential antibrucella activity of bovine and murine macrophages. Indian Journal of Experimental Biology. 2016 July; 54(7): 452-456.