Effects of isotretinoin on the thyroid gland and thyroid function tests in acne patients: A preliminary study.
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Date
2016-09
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Abstract
Background: Isotretinoin is widely used in the treatment of acne. Aims: We investigated
the effects of isotretinoin on thyroid function tests and thyroid volume in acne patients.
Methods: In this prospective study, a total of 104 acne patients were included. Sixty-six
patients were treated with isotretinoin for at least 4 months. Thirty eight patients were included
in the control group. The levels of thyroid stimulating hormone, free triiodothyronine, free
thyroxine, antithyroglobulin and antithyroid peroxidase antibodies were measured and a
thyroid ultrasound was performed in all the subjects before treatment and 4 months after
treatment. A “p” value of < 0.05 was considered signifi cant. Results: In the isotretinoin-treated
group, thyroid stimulating hormone levels increased significantly during isotretinoin
treatment (P = 0.018). Free triiodothyronine, free thyroxine, anti-thyroid peroxidase levels
and thyroid volume decreased signifi cantly during treatment (P = 0.016, P = 0.012, P = 0.006,
P = 0.020 respectively). Limitations: The major limitation of this study is the lack of follow-up
data after the cessation of isotretinoin therapy in acne patients. Conclusion: Patients treated
with isotretinoin should be monitored with thyroid function tests.
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Keywords
Acne, isotretinoin, thyroid function test, thyroid volume, vitamin A
Citation
Uyar Belkiz, Solak Aynur, Saklamaz Ali, Akyildiz Muhittin, Genç Berhan, Gökduman Ayse. Effects of isotretinoin on the thyroid gland and thyroid function tests in acne patients: A preliminary study. Indian Journal of Dermatology, Venereology and Leprology. 2016 Sept-Oct; 82(5): 587-588.