Psoriasis and risk of incident atrial fibrillation: A systematic review and meta-analysis.
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Date
2016-09
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Abstract
Background and Objectives: Patients with psoriasis might have a higher risk of developing
atrial fi brillation as a result of chronic infl ammation. This study aimed to investigate this
association by comprehensively reviewing all available evidence. Methods: We conducted
a systematic review and meta-analysis of cohort studies that reported relative risk, hazard
ratio, incidence ratio or standardized incidence ratio with 95% confi dence intervals comparing
the risk of incident atrial fi brillation in patients with psoriasis versus participants without
psoriasis. Both retrospective and prospective cohort studies were eligible. Pooled risk ratio
and 95% confi dence intervals were calculated using random-effect, generic inverse variance
methods of DerSimonian and Laird. Results: Three retrospective studies with 110,568 cases
of psoriasis and 5,352,817 participants without psoriasis were included in this meta-analysis.
The pooled risk ratio of subsequent development of atrial fi brillation in patients with psoriasis
versus participants without psoriasis was 1.21 (95% confi dence interval, 1.14–1.29). The
statistical heterogeneity was low with an I2 of 29%. Limitations: Coding-based design of the
primary studies that had limited accuracy. Conclusions: Our meta-analysis demonstrated
a statistically significant increase in the risk of incident atrial fibrillation among patients with
psoriasis.
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Keywords
Atrial fibrillation, meta-analysis, psoriasis
Citation
Ungprasert Patompong, Srivali Narat, Kittanamongkolchai Wonngarm. Psoriasis and risk of incident atrial fibrillation: A systematic review and meta-analysis. Indian Journal of Dermatology, Venereology and Leprology. 2016 Sept-Oct; 82(5): 489-498.