Cardiodepressant activity of newer dihydropyrimidine derivative in comparison to Nifedipine on perfused Rabbits heart.
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Date
2012-07
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Abstract
Background: Substituted dihydropyridine calcium channel blockers
are used in the treatment of cardiovascular diseases.
Dihydropyridines are considered as analogue of
dihydropyrimidines.
Objectives: In present study newly synthesized test compound 5-
Acyl-6-methyl-4(2’,3’-methylenedioxy) phenyl - 2 - S - ethyl - 1, 4-
dihydropyrimidine, a dihydropyrimidine derivative was
investigated with an aim to get valuable substitute for the well
known dihydropyridine, Nifedipine.
Material & Methods: The Calcium Channel blocking actiuity of test
compound was studied on Rabbit’s Heart and its effects were
compared with Nifedipine used as control.
Results: Test compound has dose-dependent negative
chronotropic and negative inotropic effect on Rabbit’s heart but
these effects appeared at doses higher than those of Nifedipine.
Test compound had no significant change in coronary flow
however Nifedipine show significant increase in coronary flow at
lower doses.
Conclusion: Test compound appears to be less potent myocardial
depressant compared to Nifedipine. Test compound produced
calcium channel blocking activity which was dose related and in
order to ascertain the status of this compound as a drug, further
studies are needed not only in other animals and tissue models but
also in various pathophysiological models.
Description
Keywords
Test compound (5-Acyl-6-methyl-4(2’,3’-methylenedioxy) phenyl - 2 - S - ethyl - 1, 4-dihydropyrimidine), DMSO (Dimethylsulphoxide), nifedipine
Citation
Kumar R, Sehgal VK, Kaur B, Kaur R. Cardiodepressant activity of newer dihydropyrimidine derivative in comparison to Nifedipine on perfused Rabbits heart. International Journal of Medical and Dental Sciences. 2012 Jul; 1(2): 6-14.