Effect of some Indian herbs on dyslipidemia in streptozotocin induced diabetic Rats.
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Date
2013-01
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Abstract
Background: Diabetes is one of the commonest and
serious metabolic disorders. Much of the morbidity and
mortality associated with diabetes is primarily attributed
to sequelae requelac of microvascular and macrovascular
changes, in which diabetic dyslipidemia is one of the
many modifiable risk factors for coronary artery disease,
stroke and peripheral vascular disease.
Objectives: The main aim of this study was to evaluate
the hypoglycemic and antidyslipidemic effect of selected
Indian plants in streptozotocin induced diabetic rats.
Material and Methods: Azadirachta indica and Ocimm
sanctum leaves, Allium sativum bulbs and Momordica
charantia fruits were collected, identified taxonomically
and extract was obtained. Male Albino rats was used and
divided into 8 groups, each consisting of 6 animals, one
group act as a control. Diabetes in rats was induced with
streptozotocin. Blood samples were collected and
biochemical analysis was done for blood sugar, lipid
peroxide and lipid profile. The diabetic group without
drug treatment was compared with the control, and
diabetic plus drug-treated groups were compared with
the diabetic group without drug treatment. Data were
analyzed using Student ‘t’ test.
Results: Our results revealed that administration of streptozotocin in rats caused increase in the levels
of glucose, lipid peroxides, cholesterol and triglycerides with lessening of the HDL-cholesterol.
Treatment with aqueous extracts of Momordica charantia, Allium sativum, Azadirachta indica and
Ocimum sanctum not only reduced the level of blood glucose but also caused lowering of total
cholesterol and triglycerides following an increase in the level of HDL-cholesterol.
Conclusion: We concluded that the herbal plants tested possess both hypoglycemic and
antidyslipidemic activities and their use as a therapeutic tool in diabetes related complications
encourage further investigation in this field.
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Keywords
Diabetes, dyslipidemia, Indian herbs, lipid peroxidation
Citation
Chandra A, Sabharwal R, Chander R, Mahdi F, Mahdi AA. Effect of some Indian herbs on dyslipidemia in streptozotocin induced diabetic Rats. International Journal of Medical and Dental Sciences. 2013 Jan; 2(1): 24-33.