Comparative evaluation of Metoprolol and Telmisartan in hypertensive patients.
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Date
2014-07
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Abstract
Background: Epidemiological studies and clinical trials have shown that
meticulous control of blood pressure is required in patients with hypertension to
ensure decreased cardiovascular morbidity and mortality.
Objective: To compare the effect of Metoprolol and Telmisartan on blood
pressure reduction and heart rate in patients of Stage I Hypertension.
Material and Methods: This was a prospective, randomized, open, parallel
study conducted at the outpatient department of Medicine. Patients of either
sex with Grade I Hypertension according to JNC VII, aged between 18-60 years
were enrolled and followed up every 2 weeks from baseline till 12 weeks.
Patients were randomly divided into two groups to receive tablet Metoprolol 50
mg (Group A, n=30) and Telmisartan 40 mg (Group B, n=30) once a day.
Response to study treatments was evaluated in terms of decrease in Blood
pressure and heart rate. Results were analysed using Student’s ‘t’ test.
Results: Baseline characters of both the groups were well balanced. Systolic
Blood Pressure was reduced by 7.5 % from Metoprolol and 12.9% by
Telmisartan and Diastolic Blood Pressure was reduced by 8.2% in group A and
13.6% in group B. Both the drugs leads to significant reductions (i.e. P <0.05) in
systolic as wel as diastolic BP. Heart rate reduction was significant and was
observed to be more with the Metoprolol group i.e. 15.2% reduction as
compared to 9.1% reduction with Telmisartan.
Conclusion: Telmisartan is a better choice than Metoprolol in Indian Population
for treating Grade I hypertension as it leads to greater reduction in Blood
Pressure and less effect on Heart rate.
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Keywords
Grade I Hypertension, metoprolol, telmisartan, systolic blood pressure, diastolic blood pressure, heart rate
Citation
Agarwal A, Chhabra MK, Walia R, Gupta PD. Comparative evaluation of Metoprolol and Telmisartan in hypertensive patients. International Journal of Medical and Dental Sciences. 2014 July; 3(2): 403-410.