Unicentric Castleman’s disease presenting as retroperitoneum lump.
Date
2015-07
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Abstract
Castleman disease is a rare lymphoproliferative disorder, also known
as giant lymph node hyperplasia or angiofollicular lymph node
hyperplasia. Clinically, Castleman disease is of two types:
localised/unicentric type and multicentric/systemic type. Unicentric or
localised Castleman disease affect a single lymph node or group of
lymph nodes. The multicentric type affects two or more groups of
lymph node in different part of the body. It can also affect organs
containing lymphoid tissue. Histologically it is classified as hyaline
vascular variant, plasma cell variant and a mixed variant. Clinical
symptoms may vary from asymptomatic to symptomatic
lymphadenopathy accompanied by fever, anaemia fatigue,
abdominal or thoracic pain and weight loss. There is no specific test to
diagnose Castleman disease. We report a case of 16 years old male
who presented with a painless lump in left lumbar region without any
constitutional symptoms. CECT suggested a retroperitoneal lump with
calcification. Laparotomy was done and complete excision of mass
done. Histopathological examination of excised tissue suggested
Castleman disease of hyaline vascular variant. After six month of
follow up, the patient has no complain.
Description
Keywords
POEMS, castleman’s disease, hyaline vascular variant, lymphoproliferative disorder, lump, lymph node
Citation
Ranjan R, Jha RK, Patro JKE, Malua S, Bodra P. Unicentric Castleman’s disease presenting as retroperitoneum lump. International Journal of Medical and Dental Sciences. 2015 July; 4(2): 852-855.