Response of peg IFN and ribavarin in HIV-HCV co-infection.
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Date
2015-07
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Abstract
Background: Hepatitis C infection is one of most common co-infection
in HIV. HIV infection influences the natural evolution of chronic
hepatitis by higher rate of viral persistence, accelerating fibrosis,
cirrhosis progressing to end-stage liver disease.
Objective: This retrospective study was conducted in order to see the
response to Peg- IFN α-2b with Ribavarin in HIV HCV co-infection.
Material and Methods: Alanine aminotransferase and Aspartate
Aminotransferase, HCV RNA quantitative and Genotype study,
Fibroscan, CD4 were collected from the medical records of ART centre.
Results: The mean baseline viral load (log10) was 5.76, 3.00 at 1st
month, 0.44 at 3rd month, 0 at 6th month and 12th month. RVR was
observed in 77.7%, EVR in 88.8%, SVR of 100% at 6th and 12th month.
The mean OT and PT reduction at 3rd month was 116.11(57.79%) and
132 (61.68%) respectively, at 6 month was 158 (78.65%) and 177.56
(82.97%) respectively, at 12th month was 159(79.14%) and 176.56
(82.50%). Fibrosis at the start of treatment was 19.0 KPa, 10.00 KPa
at 6th month and 8.20 KPa at 12th month.
Conclusion: Study shows that SVR can be achieved in HCV HIV co
infected patients with IFN and Ribavarin therapy which in turn
reduces the morbidity and mortality due to liver disease. Inspite of
virological response, few patients continue to have deranged AST and
ALT and progressive liver fibrosis.
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Keywords
Human immunodeficiency virus, hepatitis C virus, HCV RNA, fibroscan
Citation
Kumar AP, Singh NB, Romeo K, Singh TB, Ninsheng R. Response of peg IFN and ribavarin in HIV-HCV co-infection. International Journal of Medical and Dental Sciences. 2015 July; 4(2): 785-794.